Endometriosis is a condition that affects a lot of women. Endometriosis sufferers may experience difficulty getting pregnant but, fortunately, this problem does not occur in every woman. You can also search online to get more information about endometriosis causes and facts.
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Genetic predisposition plays a role in endometriosis. Sisters or daughters of those suffering from endometriosis may be at a higher risk of developing endometriosis on their own.
Low progesterone levels could be genetic and cause a hormonal imbalance. There is a 10x increase in the incidence of women who have an affected first-degree relative.
It has been suggested that endometriosis is a result of an array of hits in target genes with a similar mechanism to that of the development of cancer. In this scenario, the first mutation could be heritable or somatic.
Additionally to this, there are numerous findings of epigenetics and altered gene expression however, both could be the consequence of, for example, environmental factors as well as altered metabolism.
Aging brings various effects that could decrease fertility. The loss of ovarian follicles can affect menstrual frequency. Endometriosis takes longer to cause scarring of the ovary as well as the tubes, which means they can't move as freely or even cause the replacement of the ovarian follicular tissue when endometriosis continues to grow.
Postmenopausal women with endometriosis do occur and are classified as an aggressive type of the disease, characterized by complete progesterone resistance, as well as incredibly excessive levels of aromatase production. In less frequent instances, women may experience symptoms of endometriosis before they reach menarche.